Table 2. Pupil parameters for patients with optic nerve disease (hereditary optic neuropathy HON and glaucoma GL) and their controls (N = 44).
| Red Lights | Controls |
Patients |
||||||
|---|---|---|---|---|---|---|---|---|
| Mean Pre-LE | (SD) | Mean % Post-LE | (SD) | Mean Pre-LE | (SD) | Mean Post-LE | (SD) | |
| GL | ||||||||
| MPS (1s) | 55.5 | (4.8) | 56.6 | (8.2) | 60.9 | (6.6) | 60.9 | (8.1) |
| MPS (30s)* | 40.7 | (8.0) | 43.5 | (3.6) | 48.7 | (4.9) | 49.5 | (6.4) |
| SPS (30s)* | 48.2 | (5.3) | 50.4 | (5.2) | 55.3 | (6.3) | 56.5 | (7.0) |
| PSPS (1s)# | 92.8 | (6.1) | 89.7 | (8.8) | 95.3 | (4.2) | 90.9 | (8.2) |
| ERR (30s) | −4.78 | (0.06) | −4.80 | (0.06) | −4.81 | (0.08) | −4.87 | (0.11) |
| ARS (30s)# | 107.0 | (8.3) | 104.8 | (9.7) | 104.7 | (5.3) | 97.7 | (7.8) |
| HON | ||||||||
| MPS (1s)# | 59.2 | (4.6) | 62.9 | (5.2) | 57.1 | (6.9) | 61.0 | (6.4) |
| MPS (30s)# | 43.2 | (3.0) | 47.3 | (4.6) | 44.1 | (4.4) | 46.3 | (6.7) |
| SPS (30s) | 53.5 | (6.0) | 54.3 | (5.5) | 51.2 | (4.9) | 52.3 | (6.2) |
| PSPS (1s)# | 95.5 | (4.0) | 89.2 | (5.4) | 94.1 | (5.3) | 91.6 | (4.9) |
| ERR (30s) | −4.82 | (0.10) | −4.82 | (0.07) | −4.78 | (0.10) | −4.86 | (0.15) |
| ARS (30s) | 105.1 | (7.4) | 100.7 | (3.8) | 109.1 | (17.6) | 103.1 | (8.6) |
| Blue Lights | ||||||||
| GL | ||||||||
| MPS (1s)*,# | 46.9 | (7.5) | 50.1 | (6.1) | 53.7 | (4.0) | 55.9 | (7.2) |
| MPS (30s)* | 36.3 | (8.2) | 37.9 | (4.8) | 43.6 | (4.0) | 43.6 | (5.3) |
| SPS (30s)* | 37.6 | (7.7) | 37.4 | (5.1) | 45.6 | (4.3) | 44.2 | (5.7) |
| PSPS (1s)*,# | 56.5 | (8.4) | 64.2 | (9.9) | 66.4 | (7.3) | 73.6 | (8.9) |
| ERR (30s)* | −4.67 | (0.03) | −4.67 | (0.04) | −4.70 | (0.07) | −4.75 | (0.05) |
| ARS (30s)* | 106.4 | (14.0) | 104.0 | (7.6) | 96.9 | (13.1) | 98.6 | (8.6) |
| HON | ||||||||
| MPS (1s)# | 46.1 | (2.2) | 52.2 | (4.4) | 48.9 | (5.3) | 53.1 | (5.0) |
| MPS (30s)* | 36.9 | (2.8) | 37.3 | (4.7) | 38.6 | (3.6) | 42.0 | (5.8) |
| SPS (30s) | 38.3 | (3.5) | 38.4 | (3.2) | 40.7 | (4.1) | 40.7 | (3.8) |
| PSPS (1s)# | 55.6 | (4.7) | 68.4 | (7.6) | 62.7 | (8.1) | 69.0 | (8.3) |
| ERR (30s) | −4.72 | (0.10) | −4.69 | (0.03) | −4.72 | (0.11) | −4.75 | (0.10) |
| ARS (30s) | 103.1 | (7.6) | 104.6 | (14.5) | 104.3 | (13.2) | 103.4 | (8.3) |
Results of the pupillary light reflex (PLR) to red (at the top) and blue light (at the bottom) before (=pre-LE) the 2-hrs of bright light exposure and after constant bright light (post-LE). MPS = minimum pupil size for 1 s and 30 s light stimuli; SPS: sustained pupil size at the end of the 30 s stimulus; PSPS = post-stimulus pupil size after 1 s light stimuli; ERR = exponential re-dilation rate after 30 s stimuli (%-s); ARS = asymptotic re-dilation pupil size for the exponential fitting. All mean values are shown ± SD (in brackets) and for controls left side and patients (right side). Results for glaucoma (GL) patients and controls are shown in the first four rows and results for hereditary optic neuropathy (HON) patients and controls are shown in the lower four rows.
*Significant difference between controls and patients within a group (GL or HON).
#significant difference between pre-LE and post-LE (p < 0.05; N = 44).