Table 2. Function enrichment of up- and down-regulated age-associated genes in 7 tissues.
| Tissue | Up-regulated gene set |
Down-regulated gene set |
||||
|---|---|---|---|---|---|---|
| IDa | Description | Adj p-valb | ID | Description | Adj p-val | |
| Adipose | GO:0005578 | proteinaceous extracellular matrix | 1.52 × 10−3 | GO:0005739 | mitochondrion | 5.77 × 10−47 |
| GO:0005815 | microtubule organizing center | 2.05 × 10−2 | hsa05016 | Huntington’s disease | 5.12 × 10−8 | |
| GO:0043167 | ion binding | 3.85 × 10−2 | hsa05012 | Parkinson’s disease | 9.22 × 10−8 | |
| GO:0022900 | electron transport chain | 2.68 × 10−6 | ||||
| GO:0006631 | fatty acid metabolic process | 2.72 × 10−6 | ||||
| hsa05010 | Alzheimer’s disease | 2.03 × 10−5 | ||||
| Artery | GO:0060589 | nucleoside-triphosphatase regulator activity | 3.34 × 10−10 | GO:0030163 | protein catabolic process | 5.96 × 10−14 |
| GO:0030695 | GTPase regulator activity | 5.00 × 10−10 | GO:0005739 | mitochondrion | 1.27 × 10−6 | |
| GO:0006952 | defense response | 6.26 × 10−8 | GO:0019787 | small conjugating protein ligase activity | 2.20 × 10−5 | |
| GO:0006954 | inflammatory response | 2.35 × 10−4 | GO:0000278 | mitotic cell cycle | 1.57 × 10−3 | |
| GO:0008219 | cell death | 1.38 × 10−3 | hsa05016 | Huntington’s disease | 1.25 × 10−2 | |
| Heart | GO:0005739 | mitochondrion | 1.29 × 10−36 | |||
| GO:0006099 | tricarboxylic acid cycle | 3.20 × 10−10 | ||||
| hsa05012 | Parkinson’s disease | 8.79 × 10−8 | ||||
| hsa05016 | Huntington’s disease | 7.10 × 10−7 | ||||
| GO:0022900 | electron transport chain | 5.46 × 10−5 | ||||
| GO:0006511 | ubiquitin-dependent protein catabolic process | 2.81 × 10−4 | ||||
| Lung | GO:0005739 | mitochondrion | 9.57 × 10−5 | |||
| GO:0005764 | lysosome | 1.00 × 10−3 | ||||
| GO:0005773 | vacuole | 1.29 × 10−3 | ||||
| Muscle | GO:0016071 | mRNA metabolic process | 1.83 × 10−4 | GO:0000786 | nucleosome | 3.23 × 10−2 |
| GO:0006281 | DNA repair | 3.87 × 10−3 | ||||
| GO:0046930 | pore complex | 7.85 × 10−3 | ||||
| Nerve | GO:0048812 | neuron projection morphogenesis | 1.30 × 10−2 | |||
| GO:0048666 | neuron development | 1.47 × 10−2 | ||||
| GO:0007155 | cell adhesion | 4.99 × 10−2 | ||||
| Blood | GO:0006986 | response to unfolded protein | 1.88 × 10−4 | GO:0015031 | protein transport | 1.10 × 10−11 |
| GO:0007049 | cell cycle | 8.76 × 10−4 | GO:0016192 | vesicle-mediated transport | 1.64 × 10−8 | |
| GO:0005524 | ATP binding | 6.13 × 10−3 | GO:0007264 | small GTPase mediated signal transduction | 2.41 × 10−4 | |
| hsa04722 | Neurotrophin signaling pathway | 1.71 × 10−3 | ||||
| GO:0006915 | apoptosis | 9.28 × 10−3 | ||||
| hsa05010 | Alzheimer’s disease | 1.88 × 10−2 | ||||
| GO:0005739 | mitochondrion | 4.71 × 10−2 | ||||
aTop representative gene set categories.
bAdj. p-val denotes the Benjamini false discovery rate.