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Pathways That Can Be Therapeutically Targeted in Ewing Sarcoma and Osteosarcoma
| Molecular target |
Example of inhibitory drug |
|
|---|---|---|
| Global metastases processes | ||
| Apoptosis/Anoikis | AKT | MK-2206 |
| mTOR | Temsirolimus | |
| Angiogenesis | VEGF | Bevacizumab |
| VEGFR | Sorafenib | |
| Preferential OS processes | ||
| Invasion | c-SRC | Saracatinib |
| Migration | HGF/c-MET | PF-02341066 |
| Proliferation/survival | IGF-1R | Cixutumumab |
