Table 2.
Median and Inter-quartile Range IQR* Culture Supernatant Cytokine Concentrations (pg/ml) By Trimester
| Sample | 1st Trimester** | 2nd Trimester** | 3rd Trimester** | |||
|---|---|---|---|---|---|---|
| median | IQR | median | IQR | median | IQR | |
| IFNγ--Control | 3.2 | 3.2, 5.2 | 3.2 | 3.2, 5.5 | 3.2 | 3.2, 3.4 |
| IFNγ--PHA | 264.2 | 84.1, 502.0 | 118.7 | 24.9, 305.6 | 105.1 | 34.1, 202.3 |
| IFNγ--LPS | 15.8 | 3.2, 55.9 | 14.1 | 3.2, 44.7 | 5.5 | 3.2, 39.1 |
| IL4--Control | 3.2*** | 3.2, 3.3 | 3.2 | 3.2, 3.2 | 3.2 | 3.2, 3.2 |
| IL4--PHA | 168.3 | 42.1, 281.8 | 93.2 | 20.8, 252.0 | 70.3 | 27.7, 181.1 |
| IL4--LPS | 3.2 | 3.2, 3.2 | 3.2 | 3.2, 3.2 | 3.2 | 3.2, 3.2 |
| TNFα--Control | 79.8 | 24.9, 189.0 | 66.9 | 30.9, 120.2 | 47.0 | 25.0, 139.1 |
| TNFα--PHA | 344.5 | 265.8, 464.4 | 281.9 | 162.5, 437.9 | 268.3 | 185.9, 416.3 |
| TNFα--LPS | 591.4 | 400.8, 790.5 | 626.2 | 362.7, 906.6 | 580.8 | 356.3, 959.2 |
| IL1β--Control | 39.6 | 4.8, 77.0 | 18.3 | 4.9, 36.9 | 6.3 | 3.2, 20.9 |
| IL1β--PHA | 86.3 | 48.3, 115.9 | 71.2 | 42.4, 105.3 | 48.6 | 35.7, 83.0 |
| IL1β--LPS | 345.6 | 272.7, 613.6 | 364.2 | 206.1, 654.3 | 345.3 | 170.2, 581.0 |
| IL6--Control | 4110.7 | 865.6, 9285.0 | 3240.4 | 1393.6, 8808.8 | 2019.7 | 617.4, 7760.8 |
| IL6--PHA | 9542.1 | 8596.3, 10796.4 | 9987.4 | 6802.7, 10854.6 | 9610.4 | 7168.1, 10963.6 |
| IL6--LPS | 11070.9 | 10246.6, 11778.9 | 11270.4 | 10111.8, 11845.2 | 11136.8 | 10072.4, 12273.2 |
| IL10--Control | 195.9 | 28.9, 332.1 | 79.2 | 32.2, 331.6 | 62.8 | 22.5, 176.7 |
| IL10--PHA | 1515.1 | 1095.2, 2002.7 | 1456.6 | 785.7, 1928.2 | 1570.1 | 897.9, 2126.8 |
| IL10--LPS | 1584.4 | 1191.2, 2093.4 | 2006.8 | 1233.0, 2619.8 | 2208.6 | 1467.1, 2902.4 |
*
IQR represents the 25th and 75th percentile values for each cytokine within trimester.
**
N=45 subjects for T1, T2, and T3.
***
3.2 pg/ml was the lower limit of detection established by the reagent kit manufacturer and the lowest standard on the standard curve.