Table 2.
Associations between Merkel cell polyomavirus and cutaneous squamous cell carcinoma by tumor MCV DNA status
| Controls (N = 300) | MCV tumor-negative SCC cases (N = 89) | MCV tumor-positive SCC cases (N = 55) | p-value | |||
|---|---|---|---|---|---|---|
| MCV biomarker | n (%) | n (%) | OR (95 % CI)* | n (%) | OR (95 % CI)* | |
| Seropositivity to MCV T-Ag (>50 MFI) | ||||||
| MCV small T-Ag | 7 (2.3) | 2 (2.2) | 0.63 (0.12–3.32) | 0 (0) | Could not be estimated | 0.862 |
| MCV large T-Ag exon 1 | 3 (1.0) | 1 (1.1) | 1.11 (0.11–11.61) | 0 (0) | Could not be estimated | 0.996 |
| MCV large T-Ag exon 2 | 18 (6) | 10 (11.2) | 1.50 (0.63–3.53) | 5 (9.1) | 1.06 (0.35–3.2) | 0.640 |
| MCV large T-Ag | 22 (7.3) | 9 (10.1) | 1.10 (0.47–2.6) | 6 (10.9) | 1.06 (0.38–2.93) | 0.975 |
| Controls | MCV-DNA negative SCC cases | MCV-DNA positive SCC cases | p-value | |||
| (n = 292) | (n = 86) | (n = 55) | ||||
| n (%) | OR (95 % CI)* | n (%) | OR (95 % CI)* | |||
| MCV DNA present in eyebrow hairs | 109 (37.3) | 26 (30.2) | 0.58 (0.34–1.01) | 42 (76.4) | 4.05 (2.01–8.18) | 1.06 × 10 −6 |
MCV Merkel cell polyomavirus, SCC cutaneous squamous cell carcinoma. * Odds ratios (OR) and 95 % confidence intervals (CI) calculated separately SCC cases with or without MCV DNA in their tumors using polynomial logistic regression, adjusting for age and gender