Table 1.
Baseline characteristics of Caucasians in FACTT with genotype data (n = 307)
| Characteristic | No AKIa | Stage 1 AKIa | Stage 2 or 3 AKIa |
|---|---|---|---|
| n = 176 (57.3 %) | n = 99 (32.3 %) | n = 32 (10.4 %) | |
| Age, mean years +/− SD | 50.4 +/− 14.6 | 49.9 +/− 16.3 | 48.8 +/− 16.1 |
| Male gender | 48.9 % | 52.5 % | 62.5 % |
| Primary ALI risk factor, n (%) | |||
| Aspiration | 30 (17.1 %) | 20 (20.2 %) | 2 (6.3 %) |
| Multiple transfusions | 2 (1.1 %) | 2 (2.0 %) | 0 |
| Pneumonia | 81 (46.0 %) | 46 (46.5 %) | 11 (34.4 %) |
| Sepsis | 30 (17.1 %) | 21 (21.2 %) | 17 (53.1 %) |
| Trauma | 17 (9.7 %) | 6 (6.1 %) | 1 (3.1 %) |
| Other | 16 (9.1 %) | 4 (4.0 %) | 1 (3.1 %) |
| APACHE III score, mean +/− SDb | 84.4 +/− 25.2 | 98.8 +/− 30.4 | 117.4 +/− 26.3 |
| Randomization arm, n (%) | |||
| PAC/fluid liberal | 47 (26.7 %) | 30 (30.3 %) | 11 (34.4 %) |
| PAC/Fluid | 43 (24.4 %) | 17 (17.2 %) | 11 (34.4 %) |
| Conservative CVC/fluid | 39 (22.2 %) | 26 (26.3 %) | 8 (25.0 %) |
| Liberal CVC/fluid | 47 (26.7 %) | 26 (26.3 %) | 2 (6.3 %) |
| Vasopressor usec | 55 (31.3 %) | 35 (35.4 %) | 19 (59.4 %) |
| Patient location | 86 (48.9 %) | 58 (58.6 %) | 19 (59.4 %) |
| MICU SICU | 21 (11.9 %) | 9 (9.1 %) | 0 |
| MICU/SICU | 41 (23.3 %) | 23 (23.2 %) | 4 (12.5 %) |
| Trauma | 16 (9.1 %) | 6 (6.1 %) | 6 (18.8 %) |
| Other | 12 (6.8 %) | 3 (3.0 %) | |
| Baseline creatinined, mg/dl (SD) | 0.9 (0.4) | 1.4 (0.6) | 2.1 (1.2) |
aAcute kidney injury (AKI) study definitions: no AKI = <0.3 mg/dl and <50 % increase in serum creatinine (SCr); stage 1 AKI = > =0.3 mg/dl and > = 50 % increase in SCr; stage 2 or 3 AKI = >100 % increase in SCr. bMissing acute physiology and chronic health evaluation (APACHE) score for 9 patients, 5 five patients, and patients with no AKI, stage 1 and 2 or 3 AKI, respectively. cVasopressor use in the 24 h before Fluid and Catheter Treatment Trial (FACTT) enrollment. dBaseline creatinine based on average SCr in the 24 h before enrollment in FACTT. ALI acute lung injury, PAC pulmonary artery catheter, CVC central venous catheter, MICU medical intensive care unit, SICU surgical intensive care unit