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. Author manuscript; available in PMC: 2015 Oct 19.
Published in final edited form as: J Pathol. 2011 Oct 18;226(1):73–83. doi: 10.1002/path.2972

Figure 2.

Figure 2

Construction of ΔSAMP mice. (A) The top panel shows the wild-type allele and the lower panel shows the targeted ΔSAMP allele. Exons are numbered and restriction enzymes marked (B = BamHI; E = EcoR1; K = KpnI; Sl = SalI). (B) A cartoon showing the protein structure of APC and the deleted regions in the 1322T and ΔSAMP mutated proteins. (C) Western blot using anti-Apc antibody on tail fibroblasts derived from heterozygous 1322T and ΔSAMP mice showing the sizes of the mutated Apc protein relative to the full length 300 kD protein.