Table 1.
Cell composition and beta-catenin protein expression in adenomas
| Normal crypt | Normal crypt | Early lesions <4 crypts) | Early lesions (<4 crypts) | Late lesions (>4 crypts) | Late lesions (>4 crypts) | |
|---|---|---|---|---|---|---|
| ΔSAMP N = 10 | 1322 N = 10 | ΔSAMP N = 10 | 1322 N = 13 | ΔSAMP N = 10 | 1322 N = 13 | |
| Mean cell number/crypt cross section (range in individual crypts) |
32.5 (27–41) | 29 (26–52) | 48 (32–81) | 43 (26–56) | 54 (28–71) | 46 (30–67) |
| Mean percentage enterocytes/cross section normal crypt or lesion |
69.8 (62–82) | 76.4 (72–81) | 50.7 (30–93.1) | 57.7 (28–95) | 85.6 (71–96) | 76.5 (52–95) |
| Mean percentage Paneth cells/cross section normal crypt or lesion |
22.1 (17–27) | 18.6 (15–25) | 48 (20–67) | 40.3 (17–63) | 15.8 (7.9–28) | 21.15 (5–45) |
| Mean percentage goblet cells/cross section normal crypt or lesion |
4.9 (4–11) | 6.9 (6–8) | 0.8 (0–2) | 1.97 (0–7) | 2.2 (0–4.7) | 1.23 (0–4.8) |
| Mean percentage neuroendocrine cells/cross section normal crypt or lesion |
1.75 (0–2) | 0.4 (0–2) | 0.5 (0–1) | 0.38 (0–2) | 0.6 (0–1) | 0 |
| Mean percentage enterocytes expressing nuclear beta catenin/cross section normal crypt or lesion |
1 (0–2) | 1 (0–2) | 4.5 (0–11) | 2.6 (0–13.3) | 11.7 (2–28) | 7.5 (0–32.9) |
| Mean percentage Paneth cells expressing nuclear beta-catenin/cross section normal crypt or lesion |
47.14 (20–80) | 42.3 (25–75) | 57 (32–87) | 66.9 (24–95) | 3.4 (0–10) | 1.3 (0–3.3) |
| Mean percentage goblet cells expressing nuclear beta-catenin/cross section normal crypt or lesion |
0 | 0 | 0 | 0 | 0 | 0 |
| Mean percentage neuroendocrine cells expressing nuclear beta-catenin/cross section normal crypt or lesion |
0 | 0 | 0 | 0 | 0 | 0 |