Table 2.
Percentage growth inhibition by sesquiterpenes (1 to 7)
| Compound | ||||||
|---|---|---|---|---|---|---|
| Cell line | 1 | 2 | 3 | 4 | 5 | 6/7 |
| HT29a | 60?±?3 | 12?±?2 | 12?±?5 | >100 | <10 | 10?±?5 |
| U87b | 25?±?2 | 13?±?6 | 15?±?7 | 52?±?2 | 12?±?4 | 15?±?6 |
| MCF-7c | 81?±?6 | <10 | <10 | >100 | <10 | <10 |
| A2780d | 65?±?5 | <10 | <10 | 99?±?1 | <10 | <10 |
| H460e | 11?±?1 | <10 | <10 | 71?±?1 | <10 | <10 |
| A431f | 86?±?1 | <10 | <10 | >100 | <10 | <10 |
| Du145g | 41?±?1 | 23?±?6 | 18?±?3 | 92?±?2 | 18?±?2 | 17?±?3 |
| BE2-Ch | >100 | <10 | <10 | >100 | <10 | <10 |
| SJ-G2b | 40?±?5 | <10 | 10?±?3 | >100 | 12?±?3 | 14?±?3 |
| MIAi | 47?±?2 | 12?±?4 | 17?±?3 | 92?±?2 | 18?±?3 | 19?±?2 |
| SMAj | 34?±?8 | <10 | <10 | 95?±?1 | <10 | <10 |
| MCF10Ak | 10?±?6 | <10 | <10 | 31?±?10 | <10 | <10 |
Isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), and a 1:1 mixture of the 3?-hydroxydebromoaplysin (6) and 10-bromo-1,7-dien-3-ol (7) against a panel of cancer and non-cancer derived cell lines at a single dose (25 ?M). Values are measured relative to an untreated control. aColon; bglioblastoma; cbreast; dovarian; elung; fskin; gprostate; hneuroblastoma; ipancreas; jglioblastoma (murine); kbreast (normal).