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. 2015 Oct 1;128(19):3550–3555. doi: 10.1242/jcs.175265

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — IMPDH forms cytoophidia in specific cell types in vitro. (A–D) Immunofluorescence of mouse BNL CL2 cells that were untreated (control), cultured with serum-free medium for 1 day, or treated with 50 μM LY294002 (PI3K inhibitor) or 1 μM rapamycin (mTOR inhibitor) for 6 h before fixation. Scale bars: 20 μm. (E) Mean±s.e.m. percentages of cells with IMPDH cytoophidia after culture under various conditions. P-values were calculated with a Student's t-test. (F) Immunoblotting of BNL CL2 cells cultured under various conditions. AKT(pan), total ATK; pAKT, phosphorylated AKT. (G) A model for the regulation of IMPDH cytoophidium assembly.