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. 2015 Sep 14;4(10):1290–1297. doi: 10.1242/bio.011874

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Effects of Rac1(G12V), Rac1(G12V, Y40H), and Rac1(G12V, F37L) on mitochondria motility in vimentin-containing cells. (A-D) Cells MFT-6 were transfected with plasmids encoding Rac1(G12V, Y40H) (A,B), and Rac1(G12V, F37L) (C,D) and after 18 h were fixed and immunostained for vimentin (B,D). The partial redistribution of VIF to cellular center is seen in cells transfected with Rac1(G12V, Y40H). The margins of transfected cell in B are indicated by white dots. Scale bar, 10 μm. (E) Movements of mitochondria were analyzed in control cells and cells expressing EGFP-Rac1(G12V), Rac1(G12V, Y40H), and Rac1(G12V, F37L) stained with MitoTracker Red. Values are mean percentage of movements exceeding 0.2 μm/s±s.e.m.; n=number of cells (approximately 500 movements in each cell). *Significantly different from control (P<0.01); **no significant difference from control (P>0.80).