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. 2015 Sep 14;4(10):1270–1280. doi: 10.1242/bio.013540

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — The potential contributions of macrophages, neutrophils and intestinal epithelial cells towards intestinal inflammatory lymphangiogenesis. A model showing the potential contributions of macrophages, neutrophils and intestinal epithelial cells towards normal zebrafish intestinal vascular development (A) and zebrafish IIL (B). In the absence of inflammation, vegfaa/c-expressing zebrafish intestinal epithelial cells may contribute to vascular development in the intestine. In TNBS-treated larvae, vegfaa/c/d-expressing macrophages are required to induce inflammatory lymphangiogenesis in the intestine.