Skip to main content
. 2015 Oct 1;8(10):1311–1321. doi: 10.1242/dmm.019398

Fig. 5.

Fig. 5.

TLRs in DAMP-induced inflammatory response. Expression of Ccl2, Tnfα, Tlr2 and Tlr4 in mPTCs from Tlr2−/−, Tlr4−/− and WT mice treated with 5 µg/ml human HSP70 (A) and 5 µg/ml human HMGB1 (B) for 8 h. ***P<0.001 by Student's t-test. (C) Expression of CCL2 and TNFA in TLR2- and TLR4/CD14/MD2-overexpressing HEK293T cells treated with 40 µg/ml human HSP70 for 8 h. **P<0.01 by one-way ANOVA followed by Dunnett's test. (D) The proposed model of the albumin-HSP70-TLR4 axis in renal tubular inflammation.