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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2015 Nov;74(11):1071–1076. doi: 10.1097/NEN.0000000000000252

Table 2.

Patterns of Brain and Spinal Cord SV40 Infection of 6 SIV-infected Rhesus Macaques

Brain Spinal cord
Animal # Lesion
pattern		 Demyeli-
nation		 Neuronal
SV40
infection		 Euthanasia due
to neurological
signs		 SV40
infected cell
type		 Demyeli-
nation		 Lesion
1 PML Yes Yes Yes Glial cells in GM No None
2 PML Yes Yes Yes Glial cells in WM and GM; Meningeal cells Yes (large) PML and ME
3 PML, ME Yes Yes Yes Glial cells in GM No Gliosis
4 ME No Yes Yes Glial cells in WM and GM; Meningeal cells No ME; Perivascular lymphocytic cuff in meninges
5 PML,ME Yes No No Glial cells in WM and GM; Meningeal cells Yes (small) PML
6 ME No No Yes Glial cells in GM Negative ME; Perivascular lymphocytic cuff in GM and meninges

PML, Progressive multifocal leukoencephalopathy; ME, Meningoencephalitis or meningitis; GM, Gray matter; WM, White matter; SV40, Simian virus 40.