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. 2015 Jan 12;17(3):410–413. doi: 10.1021/ol503545j

Scheme 4. Scope of Aryl Halides in the α-Arylation of Phenyl Acetic Acid,b.

Scheme 4

Reaction conducted on a 0.1 mmol scale at 0.05 M. b Isolated yield after chromatographic purification. c 2 equiv of 1a and 4 equiv of KN(SiMe3)2. d 10 mol % Pd(OAc)2/15 mol % NiXantphos.