Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Hepatic necrosis
RCT 3-armed trial	40 people with blood concentrations of paracetamol above the UK standard treatment line at time of study In review	Grade III hepatic necrosis 0/9 (0%) with methionine 6/10 (60%) with usual care	P <0.05 Possible bias due to sealed envelope allocation; for full details, see Further information on studies Interpretation of liver biopsy results was difficult; see Further information on studies for details	Effect size not calculated	methionine
Liver enzyme levels
RCT 3-armed trial	40 people with blood concentrations of paracetamol above the UK standard treatment line at time of study In review	Peak aspartate aminotransferase greater than 1000 U 1/13 (8%) with methionine 8/13 (62%) with usual care	RR 0.13 95% CI 0.02 to 0.86 NNT 2 95% CI 2 to 6	Large effect size	methionine