Skip to main content
. Author manuscript; available in PMC: 2015 Oct 19.
Published in final edited form as: J Biol Chem. 2007 Aug 7;282(39):28609–28618. doi: 10.1074/jbc.M703796200

FIGURE 9. A schematic presentation for the anticancer mechanisms of EF24 shown in the present study.

FIGURE 9

EF24 up-regulates PTEN expression through the inhibition of proteasomal degradation of PTEN. Activation of PTEN down-regulates pAkt and MDM2, which enhances the level of p53. The up-regulation of PTEN by EF24 leads to the PTEN-mediated cell cycle progression, and increase in sensitivity to apoptosis through the activation of FasL.