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. Author manuscript; available in PMC: 2015 Oct 19.
Published in final edited form as: Nat Rev Genet. 2014 Mar 11;15(4):234–246. doi: 10.1038/nrg3663

Figure 1. Features of CTCF binding sites in the genome.

Figure 1

CTCF binding sites are associated with different genetic elements. The majority of sites are intergenic and co-localize with cohesin. In addition, a fraction of CTCF binding sites are located near RNA polymerase III (RNAPIII) type II genes (e.g. tRNA and SINE elements) and ETC loci, suggesting that TFIIIC and CTCF may cooperate in some aspects of the function of this protein. The 12 bp consensus sequence of CTCF sites is embedded within binding modules 2 and 3 as determined by the ChIP-exo technique. DNA methylation (filled red ball) of cytosine residues occurs at positions 2 and 12 of the consensus sequence in a subset of CTCF sites.