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. Author manuscript; available in PMC: 2015 Oct 19.
Published in final edited form as: Nat Rev Genet. 2014 Mar 11;15(4):234–246. doi: 10.1038/nrg3663

Figure 4. CTCF facilitates endodermal enhancer-promoter interactions in ESCs.

Figure 4

Recruitment of TAF3 at endodermal enhancers by CTCF and chromatin looping activates Mapk3 in ESCs. Apart from being a component of TFIID at core promoters, TAF3 may also associate with other transcription factors across the genome in ESCs. For instance, TAF3 represses the activity of pluripotency-associated transcription factors (OCT4, SOX2 and NANOG).