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. Author manuscript; available in PMC: 2015 Oct 19.
Published in final edited form as: Nat Rev Genet. 2014 Mar 11;15(4):234–246. doi: 10.1038/nrg3663

Figure 6. CTCF promotes alternative mRNA splicing.

Figure 6

Mutually exclusive DNA methylation and CTCF binding may regulate alternative splicing. At the CD45 gene, DNA methylation at exon 5 inhibits CTCF binding, which leads to fairly unimpeded transcriptional elongation by RNA polymerase II (RNAPII) and subsequent exclusion of exon 5 during splicing of the resultant mRNA (upper panel). By contrast, hypomethylation of exon 5 leads to CTCF binding and RNAPII stalling, which promotes the inclusion of exon 5 (lower panel).