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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Biochem Pharmacol. 2015 Sep 21;98(1):167–181. doi: 10.1016/j.bcp.2015.09.004

Table 2.

Inhibition of fatty acid transport by Lipofermata/CB16.2 and related compounds

Structural similarities and differences Caco2 HepG2 Adipocytes C2C12 INS-1E
Name/Designation R1 R2 R3 R4 IC50 µM (SEM)a
graphic file with name nihms725176t1.jpg graphic file with name nihms725176t2.jpg graphic file with name nihms725176t3.jpg -H graphic file with name nihms725176t4.jpg 6.09±1.00 2.74±0.90 39.34±9.34 5.67±1.35 4.65±1.56
CB16.3
graphic file with name nihms725176t5.jpg graphic file with name nihms725176t6.jpg -H graphic file with name nihms725176t7.jpg 22.08±7.17 9.40±2.22 30.24±6.41 8.95±1.10 3.80±0.46
graphic file with name nihms725176t8.jpg graphic file with name nihms725176t9.jpg -CH3 graphic file with name nihms725176t10.jpg 16.33±4.44 14.64±4.30 27.54±5.99 12.89±1.43 4.75±0.62
CB16.5
graphic file with name nihms725176t11.jpg graphic file with name nihms725176t12.jpg -CH3 graphic file with name nihms725176t13.jpg 56.70±8.83 40.00±12.95 53.19±16.39 30.67±3.76 11.27±3.46
Missing graphic file with name nihms725176t14.jpg -H graphic file with name nihms725176t15.jpg 532.00±250 191.20±94 Not effective Not
Effective		 Not
Effective
a

Data derived from log dose response curves analyzed using Prism 5.0. Values indicate the mean ± of three independent experiments.