Table V.
Characteristics of the lyophilized NAd | Formulations | ||||
---|---|---|---|---|---|
F1a | F2b | F3c | |||
At flow rate of ~15 L//min | % EFe | 74.9 ± 6.1 | 69.3 ± 5.5 | 86.5 ± 8.6 | |
% RFf | < 5.7 | 96.3 ± 1.8 | 97.5 ± 1.3 | 97.9 ± 0.3 | |
< 3.3 | 77.6 ± 3.9 | 81.2 ± 5.2 | 75.3 ± 1.7 | ||
MMADg | 1.7 ± 0.1 | 1.5 ± 0.1 | 1.9 ± 0.3 | ||
GSDh | 2.4 ± 0.2 | 2.3 ± 0.1 | 2.3 ± 0.3 | ||
At flow rate of ~30 L//min | % EFe | 75.3 ± 7.3 | 70.2 ± 4.1 | 81.2 ± 12.9 | |
% RFf | < 5.7 | 97.1 ± 0.2 | 96.8 ± 1.5 | 96.9 ± 1.4 | |
< 3.3 | 84.3 ± 3.9 | 87.7 ± 1.5 | 82.3 ± 4.2 | ||
MMADg | 1.3 ± 0.2 | 1.2 ± 0.04 | 1.6 ± 0.3 | ||
GSDh | 2.3 ± 0.3 | 2.3 ± 0.4 | 2.3 ± 0.1 | ||
At flow rate of ~60 L//min | % EFe | 77.4 ± 6.6 | 72.2 ± 5.9 | 82.9 ± 12.7 | |
% RFf | < 5.7 | 95.8 ± 0.2 | 95.9 ± 1.5 | 95.7 ± 1.7 | |
< 3.3 | 87.1 ± 2.3 | 89.3 ± 2.5 | 83.6 ± 2.8 | ||
MMADg | 1.1± 0.2 | 1.1 ± 0.1 | 1.3 ± 0.2 | ||
GSDh | 2.3 ± 0.1 | 2.3 ± 0.2 | 2.3 ± 0.1 |
F1 = 0.1: 0.02; Bud: Lec
F2 = 0.1: 0.02: 0.01; Bud: CA: PL
F3 = 0.2: 0.04: 0.02; Bud: CA: PL
NA: Nanoparticle agglomerates.
% EF: Percent emitted fraction.
RF: Percent respirable fraction.
MMAD: Mass median aerodynamic diameter.
GSD: Geometric standard deviation.