Table V.

Cascade impaction results of lyophilized budesonide nanoparticle agglomerates (values = average ± S.D.).

Characteristics of the lyophilized NAd			Formulations
			F1a	F2b	F3c
At flow rate of ~15 L//min	% EFe		74.9 ± 6.1	69.3 ± 5.5	86.5 ± 8.6
	% RFf	< 5.7	96.3 ± 1.8	97.5 ± 1.3	97.9 ± 0.3
		< 3.3	77.6 ± 3.9	81.2 ± 5.2	75.3 ± 1.7
	MMADg		1.7 ± 0.1	1.5 ± 0.1	1.9 ± 0.3
	GSDh		2.4 ± 0.2	2.3 ± 0.1	2.3 ± 0.3
At flow rate of ~30 L//min	% EFe		75.3 ± 7.3	70.2 ± 4.1	81.2 ± 12.9
	% RFf	< 5.7	97.1 ± 0.2	96.8 ± 1.5	96.9 ± 1.4
		< 3.3	84.3 ± 3.9	87.7 ± 1.5	82.3 ± 4.2
	MMADg		1.3 ± 0.2	1.2 ± 0.04	1.6 ± 0.3
	GSDh		2.3 ± 0.3	2.3 ± 0.4	2.3 ± 0.1
At flow rate of ~60 L//min	% EFe		77.4 ± 6.6	72.2 ± 5.9	82.9 ± 12.7
	% RFf	< 5.7	95.8 ± 0.2	95.9 ± 1.5	95.7 ± 1.7
		< 3.3	87.1 ± 2.3	89.3 ± 2.5	83.6 ± 2.8
	MMADg		1.1± 0.2	1.1 ± 0.1	1.3 ± 0.2
	GSDh		2.3 ± 0.1	2.3 ± 0.2	2.3 ± 0.1

^aF1 = 0.1: 0.02; Bud: Lec

^bF2 = 0.1: 0.02: 0.01; Bud: CA: PL

^cF3 = 0.2: 0.04: 0.02; Bud: CA: PL

^dNA: Nanoparticle agglomerates.

^e% EF: Percent emitted fraction.

^fRF: Percent respirable fraction.

^gMMAD: Mass median aerodynamic diameter.

^hGSD: Geometric standard deviation.