Table II. Classification of animal models of anxiety. BZD, benzodiazepine; 5-HT, serotonin; CCK, cholecystokynin; AD, adrenergic; GLU, glutamate; CRF, corticotropin-releasing factor; EPM, elevated plus maze; L/D, light/dark; FP, four-plate; ++: anxiolytic-like effect; +: anxiolytic-like effect or no effect, anxiogenic effect; 0: no effect.

Animal models	BZD agonists	5-HT1A agonists	5-HT2A/2C antagonists	5-HT3 antagonists	CCK-2 antagonists	AD agents	GLU	CRF
EPM	++	+	+	+	+	++		++
L/D	++	++	+	+	+	-		++
FP	++	++	++	0	NA	++	++