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. Author manuscript; available in PMC: 2016 Jul 2.
Published in final edited form as: J Phys Chem Lett. 2015 Jun 18;6(13):2546–2553. doi: 10.1021/acs.jpclett.5b00957

Figure 4.

Figure 4

Cartoon illustration of the free energy landscape of the unconstrained (pink) and constrained (blue) Trp-cage peptide, showing that the cross-linker increases the internal friction of the folding process.