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. Author manuscript; available in PMC: 2016 Sep 24.
Published in final edited form as: J Med Chem. 2015 Sep 11;58(18):7419–7430. doi: 10.1021/acs.jmedchem.5b00930

Figure 4.

Figure 4

(A) Proposed mechanistic pathways for oxygen-mediated decomposition of 1. Intermediates highlighted in yellow exhibit m/z [M+H]+ = 446.1, which is observed in the LC-MS analysis.