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. 2015 Oct 13;11:2649–2657. doi: 10.2147/NDT.S92158

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© 2015 Lu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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HA treatment decreased mitochondrial injury and apoptosis.

Notes: (A) After ICH, HA was injected and mitochondrial injury was recorded. Compared to the vehicle group, HA significantly reduced the mitochondria damage score. (B) Apoptosis was analyzed by TUNEL, and fewer apoptotic cells were observed in HA-treated animals. TUNEL-positive cells are shown in red (arrows), and all cells were counterstained with DAPI (blue). Arrows in (A): swollen mitochondria, (B): TUNEL-positive cells. Scale bars represent 250 nm in (A) and 10 μm in (B). *P<0.05 compared with the vehicle group.

Abbreviations: HA, Huperzine A; ICH, intracerebral hemorrhage; TUNEL, transferase dUTP nick end labeling; DAPI, 4′,6-diamidino-2-phenylindole; Sal, saline.