Table S3.

Temperature coefficients of the AMC peptide in H₂O/D₂O (90/10)

Residue	Δδ/ΔT (ppb/K)
1 C	–
2 P	–
3 I	−9.0±0.3
4 F	−7.5±0.3
5 T	−4.1±0.3
6 K	−5.5±0.4
7 I	−6.4±0.3
8 Q	−8.4±0.2
9 G	−5.9±0.7
10 T	−4.9±0.5
11 C	−7.7±0.3
12 G	−7.83±0.07
13 G	−5.67±0.23
14 R	−6.4±0.2
15 R	−7.9±0.8
16 K	−7.5±0.4
17 K	−7.9±0.2

Notes: Data are presented as mean ± standard deviation.

Abbreviations: AMC, antimicrobial cyclic peptide; D₂O, deuterium oxide; C, cysteine; P, proline; I, isoleucine; F, phenylalanine; T, threonine; K, lysine; Q, glutamine; G, glycine; R, arginine.