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. Author manuscript; available in PMC: 2015 Oct 19.
Published in final edited form as: Nat Genet. 2015 Jun 1;47(7):757–765. doi: 10.1038/ng.3319

Figure 6.

Figure 6

Topography of ATF6A and the location of the disease-causing variants identified in patients with ACHM. The diagram depicts the transactivation domain, including the VN8 domain, the bZIP domain and an ERTM domain39. In the C-terminal region, a domain of unknown function that is conserved between ATF6A and ATF6B is also indicated. VN8, eight-residue domain homologous to herpes simplex viral protein VP16 necessary for optimal transcriptional activity and degradation31; bZIP, basic leucine-zipper domain; ERTM,