Table 3.

Clinical Global Impression Scale Scores and Calibration Vignette

Score	CGI-S:	CGI-I:	Calibration Vignette Example
1	Normal, not at all ill	Very much improved	Baseline Severity: 5 She is a 17yo who can walk independently although she frequently needs assistance with initiation. She vocalizes only and does so infrequently. She does not reach out or hold a bottle. She maintains infrequent eye contact for 10-20 seconds. She uses the iPad for communication by pointing with her nose and consistently makes choices >50%. She breath holds <10% of the time, no hyperventilation. Her extremities are pink and cool without cyanosis. Her seizures are controlled with medications and a vagal nerve stimulator. Day 14 Severity: 5 Improvement: 3 She comes back today and her caretaker complained of irritability she attributed to GI upset and loose stool and was given several days of pepto bismol and mylanta. Positive changes reported by caretaker included more vocalizations, decreased hand wringing and relaxed arms and legs. She also reported increased stamina with walking and stationary bike. There were no remarkable changes on exam during visit.
2	Borderline ill	Much improved
3	Mildly ill	Minimally improved
4	Moderately ill	No change
5	Markedly ill	Minimally worse
6	Severely ill	Much worse
7	Extremely ill	Very much worse