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Biochemical activities of regorafenib in in vitro kinase assays
| Kinase targets55 | Regorafenib IC50 (nM) ± SD |
|---|---|
| VEGFR1 | 13±0.4 |
| TIE2 | 311±46 |
| PDGFR-β | 22±3 |
| FGFR1 | 202±18 |
| KIT | 7±2 |
| RET | 1.5±0.7 |
| RAF-1 | 2.5±0.6 |
| B-RAF | 2.5±10 |
| B-RAFV600E | 19±6 |
Abbreviations: IC50, inhibitory concentration of 50%; SD, standard deviation.
