Table 3.

Hepatitis B reactivation by demographic and clinical characteristics.

	Proportion of reactivation		Survival analysis
	n/total	%	Unadjusted HR (95%CI)
Demographic characteristics
Age at study entry (years)
18–29	13/117	11%	1.00
30–39	8/113	7%	0.62 (0.36–1.50)
40–49	3/92	3%	0.28 (0.08–0.99)*
50+	12/92	13%	1.14 (0.52–2.49)
Sex
Females	14/235	6%	1.00
Males	22/179	12%	2.33 (1.19–4.57)*
Ethnic group
Alaska/American Indian	2/31	6%	0.72 (0.17–3.00)
Aleut	5/30	17%	2.25 (0.87–5.82)
Eskimo	29/353	8%	1.00
Clinical characteristics
Age at first positive HBsAg (years)
<10	15/137	11%	1.00
10–19	6/95	6%	0.56 (0.22–1.45)
20–29	3/78	4%	0.32 (0.09–1.12)
30–39	8/60	13%	1.12 (0.47–2.64)
40–49	1/23	4%	0.39 (0.05–2.94)
50+	3/21	14%	1.35 (0.39–4.68)
Body mass index
Normal (<25)	12/114	11%	1.00
Overweight (25–29)	14/106	13%	1.30 (0.60–2.81)
Obese (≥30)	10/148	7%	0.61 (0.26–1.41)
HBV DNA levels) at study entry (IU/mL)
<29	8/185	4%	1.00
29–199	5/55	9%	2.21 (0.72–6.75)
200–999	10/119	8%	2.05 (0.81–5.20)
1000–1999	13/55	24%	5.84 (2.42–14.1)***
HBV genotype
A	5/57	9%	1.18 (0.36–3.86)
B	2/9	22%	6.76 (1.36–33.8)*
C	2/23	9%	1.14 (0.23–5.65)
D	18/209	9%	1.10 (0.44–2.79)
F	6/71	8%	1.00

HR, Hazard Ratio; CI, confidence interval; HBV, hepatitis B virus.

^*p < 0.05.

^***p < 0.001.