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Heat-killed cells of two different ZNF2-overexpressing strains offer protection to the host. (A) Strategy of vaccination. (B) Cellular morphology of the PGPD1-ZNF2 strain and the PCTR4-2-ZNF2 strain. Bar, 5 µm. (C) Survival curves of mice vaccinated by heat-killed (HK) cells of strain H99 (n = 10), PGPD1-ZNF2 (n = 4), or PCTR4-2-ZNF2 (n = 4). (E) Fungal burden in the lungs of immunized animals at the end of the experiment (60 days postchallenge).
