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. 2014 Jun 2;155(8):3088–3097. doi: 10.1210/en.2014-1110

Figure 2.

Figure 2.

Kiss1r haplo-insufficiency causes a precocious decline of ovarian follicular reserve and ovulatory defects. A and B, Representative photomicrographs of ovaries from 16-week-old WT (Kiss1r+/+) and heterozygous (Kiss1r+/−) mice. C, Number of preantral and antral follicles in each genotype. D, Percentage of dead oocytes within the ovary at 16 weeks compared with the total number of oocytes counted. E–J, Thirty-two week old ovaries from WT (E, higher magnification in I) and Kiss1r+/− mice (F, higher magnification in J). G, Number of preantral and antral follicles per ovary. H, Percentage of dead oocytes within the ovary at 32 weeks compared with the total number of oocytes counted. K, Mean number of ovulations at 16 and 32 weeks of age. For each genotype and age point, 6–8 independent ovaries per animals were used. *, P < .05; and **, P < .01 vs WT control. CL, corpus luteum; RCL, regressing corpus luteum; GF, growing follicle; AtF, atretic follicle; OC, ovarian cortex.