Figure 3.

Development of PDX tumors of different origin (lymphocytic tumor and adenocarcinoma) from the same patient tumor sample. (A) Breast PDX tumor model. First passage of breast PDX tumor (PCF #373342) grew as lymphocytic neoplasm in one mouse and as a poorly differentiated adenocarcinoma in another mouse after the initial SC transplantation of the same sample of a metastatic pleural effusion obtained from a breast cancer patient. (B) Pancreatic PDX tumor model. After initial SC transplantation of human primary pancreatic tumor (PCF #379419) into NSG mice, one mouse developed a B-cell PDX tumor, whereas another mouse developed an SC T-cell PDX tumor. The T-cell PDX tumor did not grow after retransplantation, whereas the B-cell PDX tumor progressed to a nonmetastatic pancreatic PDX tumor (adenocarcinoma) after retransplantation.