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Streptococcal pyrogenic exotoxin A (SPEA)- induced cytokines. CD14+ monocytes were stimulated with increasing concentrations of SPEA. 24 h after stimulation supernatants were analyzed by ELISA for (A) IL-6, (B) TNF, (C) IL-12p40 and (D) IL-10 (mean ± SD, n = 5). Statistical analysis was performed using a Multiple Comparison of Means (Tukey Contrasts). Significance code: 0 ‘∗∗∗’; 0.001 ‘∗∗’; 0.01 ‘∗’.
