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. 2015 Oct 20;7:204. doi: 10.3389/fnagi.2015.00204

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Copyright © 2015 Qi, Yin, Wang, Jiang, Wang, Ren, Su, Lei and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Muscular fibrosis was increased by PGC-1α knockdown and SOD1(G93A). (A) The representative pictures of Sirius staining of gastrocnemius muscle from wild-type or SOD1(G93A) mice received different treatment. (B) Quantitative analysis of collagen volume fraction of mouse gastrocnemius muscles. Data were expressed as mean ± SD (n = 10). *p < 0.05 vs wild-type mice treated with shControl and PBS; ^#p < 0.05 vs SOD1(G93A) mice treated with shControl and PBS; ^∧p < 0.05 vs wild-type mice treated with shPGC-1α and PBS; and ⁺p < 0.05 vs SOD1(G93A) mice treated with shPGC-1α and PBS.