Table 3.
Main causes of hepatic iron overload according to the histological type of siderosis and associated lesions
Parenchymal iron overload | ||
With normal liver | ||
Early genetic hemochromatosis | ||
Nontransfused dysmyelopoiesis | ||
Hereditary aceruloplasminemia | ||
With cirrhosis | ||
Iron overload secondary to cirrhosis | ||
Mixed iron overload | ||
With normal liver | ||
Insulin resistance syndrome | ||
Ferroportin disease | ||
Transfused dysmyelopoiesis | ||
Oral or parenteral iron supplementation | ||
With steatosis or steatohepatitis | ||
Insulin resistance syndrome | ||
Chronic alcoholism | ||
With chronic hepatitis | ||
Hepatitis C or B | ||
Wilson's disease | ||
With intrahepatocytic inclusions | ||
Porphyria cutanea tarda | ||
With cirrhosis | ||
Late genetic hemochromatosis | ||
Mesenchymal iron overload | ||
With normal liver | ||
Inflammatory syndrome | ||
Repeated transfusions |