Table 3. A partial list of candidate genes revealed by DCMS analysesa.
Chr. | Gene b | Position (kb)2 | P-value | Skin color | Function/association (Reference) |
---|---|---|---|---|---|
1 | DCT | 145325;145275; | 0.011;0.037; | Y;W; | Pathway: Melanogenesis, organism-specific biosystem, Pigmentation (Anno et al., 2010) |
1 | TYR | 187125; | 0.017; | Y; | Melanogenesis (Anno et al., 2010) |
3 | OSTM1 | 67325;65875; | <0.001;0.047; | Y;W; | Pigmentation (Anno et al., 2010) |
5 | OTX2 | 51375; | 0.003; | W; | The developing retinal pigment epithelium (Nishihara et al., 2012) |
11 | MC1R | 18275;18275; | <0.001;0.044; | Y;W; | The regulation of coat, skin and feather color (http://www.chickencolours.com/Pigment%20holes%20Paint%20Silkies.pdf) |
12 | MITF | 15375;15425; | 0.008;0.021; | Y;W; | Regulating the differentiation of pigment cells (Tsukiji et al., 2009) |
20 | ASIP | 1425; | <0.001; | Y; | Pigmentation in skin (yellow) and feather (Nadeau et al., 2008) |
20 | EDN3 | 11175; | 0.003; | Y; | Promoting melanoblast proliferation (Dorshorst et al., 2011) |
24 | BCO2 | 6125;6125; | <0.001;0.003; | Y;W; | The deposition of yellow carotenoids in the skin (Eriksson et al., 2008) |
All related genes are close to potential selection regions. See Supplementary Table S4
.
This column presents the middle position of selection regions, the bold and italics represent the genes without detailed annotation in chicken.