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A look at the amyloid cascade hypothesis focusing on the imbalance between Aβ production and clearance. Aging, inflammation, and ApoE4 affect Aβ clearance by networking at the level of the neurovascular unit and the intra- and extracranial fluid circulation systems. Likewise, modifiers that feed the imbalance are categorized under three domains: detrimental lifestyle and trauma, additional genetic risk factors, and CSF outflow disorders.
