Table 3.

Cholangiocarcinoma marker genes with promoter putative STAT responsible elements

Cholangiocarcinoma altered genes1	Direction of alteration1	Putative STAT responsible elements	Regulation by STAT	References
HGF	Up	STAT3	Up	[113,114]
VEGF	Up	STAT3	Up	[157]
COX-2	Up	STAT3, STAT5	Up	[158]
Cyclin D1	Up	STAT5	Up	[16,155]
p53	Down and up	STAT1	Up	[159]
p21waf1/cip1	Down	STAT1, STAT3, STAT5	Up	[155,160,161]
p27kip1	Down	STAT3	Up	[162]
Bcl-2	Up	STAT3	Up	[16]
Bcl-Xl	Up	STAT3, STAT5	Up	[155,163]
Mcl-1	Up	STAT3	Up	[111,112]
MUC1	Up	STAT3, STAT1	Up	[164]
MUC4	Up	STAT	Up	[165]

¹Altered genes and direction of changes of their expression are adopted from[2].