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. 2015 May 29;9(11):2423–2434. doi: 10.1038/ismej.2015.53

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Copyright © 2015 International Society for Microbial Ecology

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Seasonal variations in the wild mouse gut microbiota. (a) The first principle coordinate from a Bray–Curtis-based analysis of microbial community structure over time. Trend lines were generated by fitting a polynomial function to values from each year (GraphPad Prism version 6.0). Values are mean±s.e.m. (n=14–80 samples per group). Values from June and July were combined in 2011 owing to limited available samples in July (n=2). (b) Association between average monthly microbial community structures between years. Values are mean (thick black line) and 95% CI (thin grey lines) from a linear regression. (c) The relative abundance of bacterial genera in spring and fall of both years. Values are mean±s.e.m. (n=24–123 samples per group; the first sample from each mouse was included). Asterisks represent significant differences (P-value<0.05, Wilcoxon rank-sum test).