(a) Growth (cells l−1) of isolate MMS-2-53 (‘Ca. Methylopumilus planktonicus') in sterile lake water containing different amounts of methanol. (b, c) Cell volumes (μm3) of strain MMS-2-53 during growth and in situ in Lake Zurich at different depths and during different periods of the year (c, insert). spring incr., LD28 population increase in 5 m depth in spring; spring decl., population decline in 5 m depth in spring; hypolimn., LD28 in the hypolimnion (80 m depth); autumn incr., LD28 population increase in 5 m depth in autumn.