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. 2015 Sep 28;112(41):12812–12817. doi: 10.1073/pnas.1507094112

Fig. S1.

Fig. S1.

Characterization of miR-17∼92 expression and its validated target gene expression in primary ECs derived from 17∼92 EC KOTie2 and 17∼92 EC KOVE-Cad mice. (A and B) qRT-PCR analysis of cultured primary ECs demonstrating a marked reduction of precursor miR-17∼92 (pri) and its mature derivatives. Data are normalized to WT primary ECs and represent the average of three independent isolations. *P < 0.05. (C) qRT-PCR of primary ECs derived from 17∼92 EC KOVE-Cad animals for detection of mature components of miR-17∼92 and its paralogs. Data are normalized to WT primary ECs and are derived from freshly isolated heart ECs pooled from three animals per group. (D) Expression of validated targets of miR-17∼92 examined via qRT-PCR in primary ECs from WT and 17∼92 EC KOTie2 mice. Data represent fold change compared with primary WT ECs and are derived from at least three independent isolations. *P < 0.05.