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. 2015 Sep 29;112(41):12840–12845. doi: 10.1073/pnas.1510483112

Fig. 5.

Fig. 5.

Bipolar cell GABAA receptor alterations in VIAAT deficient retina are due to impaired vesicular GABA release from amacrine but not horizontal cells. (A) α1-subunit-containing GABAA (GABAAα1) receptor immunolabeling in outer (OPL) and inner (IPL) plexiform layers of adult VIAAT knockout (KO) and littermate control (Ctrl) retinas (n = 10 KO–Ctrl pairs). (B) GABAAα1 immunoreactivity when VIAAT is selectively deleted in horizontal cells (HCs) using Cx57-Cre mice (HC VIAAT KO; n = 3 KO–Ctrl pairs). (C) Quantification of the % of pixels in the GABAAα1 receptor channel above background in OPL and IPL of Ctrl and HC VIAAT KO retinas. Number of animals is shown in parentheses.