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Sulfation enhances antigen binding of plant-derived PG9 and RSH
| Antibody | EC50 (ng/mL) | |
| gp120 | gp140 | |
| CHOPG9 | 89 ± 2 | 290 ± 85 |
| ΔXFPG9 | 421 ± 42 | 4,870 ± 1105 |
| ΔXFPG9Sulf | 92 ± 9 | 490 ± 170 |
| ΔXFPG9SulfSia | 101 ± 7 | 310 ± 30 |
| ΔXFRSH | 179 ± 49 | 2,230 ± 115 |
| ΔXFRSHSulf | 82 ± 19 | 180 ± 5 |
| ΔXFRSHSulfSia | 73 ± 13 | 180 ± 25 |
Binding of PG9 and RSH to immobilized monomeric gp120ZM109 or trimeric gp140BG505.SOSIP.664 was measured by ELISA. Data are presented as means ± SEM of two or three independent experiments.
