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In vivo PET imaging of dual EGFR and CD105 expression with Bs-F(ab)2 tracer in U87MG tumor-bearing mice. Serial coronal PET images of 64Cu-NOTA-Bs-F(ab)2 (A), its PET/CT rendering at 36 h p.i. (B), 64Cu-NOTA-CET-Fab (C), and 64Cu-NOTA-TRC105-Fab (D) at 3, 15, 24, and 36 h p.i. of each tracer. Both EGFR (E) and CD105 (F) blocking resulted in a significant decrease in U87MG tumor uptake of 64Cu-NOTA-Bs-F(ab)2 (n = 4).
