Table S3.

Ex vivo biodistribution of the tracers at 36 h after i.v. administration into U87MG tumor-bearing mice

Tissue	64Cu-NOTA-Bs-F(ab)2, n = 4	64Cu-NOTA-CET-Fab, n = 3	64Cu-NOTA-TRC105-Fab, n = 4	EGFR blocking, n = 3	CD105 blocking, n = 4
U87MG	42.91 ± 9.50	11.15 ± 4.00	10.98 ± 5.33	14.95 ± 1.78	9.99 ± 3.33
Blood	6.61 ± 6.43	3.48 ± 2.87	3.88 ± 2.11	4.69 ± 0.67	6.73 ± 2.20
Skin	2.41 ± 1.00	4.54 ± 3.35	2.04 ± 0.61	2.20 ± 0.84	3.76 ± 1.34
Muscle	0.42 ± 0.24	0.22 ± 0.06	0.52 ± 0.12	0.42 ± 0.12	0.52 ± 0.16
Bone	1.72 ± 0.85	2.29 ± 1.20	0.79 ± 0.32	0.93 ± 0.71	0.98 ± 0.37
Heart	2.29 ± 0.89	1.47 ± 0.77	1.91 ± 0.42	1.49 ± 0.19	2.69 ± 0.25
Lung	2.81 ± 1.99	1.89 ± 0.99	2.15 ± 1.63	1.89 ± 0.53	2.73 ± 0.74
Liver	8.57 ± 1.11	3.12 ± 0.34	4.36 ± 0.49	4.10 ± 1.41	8.86 ± 1.46
Kidney	7.13 ± 0.67	3.73 ± 0.85	15.99 ± 3.88	4.11 ± 1.13	5.77 ± 2.04
Spleen	6.63 ± 3.34	4.41 ± 3.29	3.10 ± 0.98	2.22 ± 0.73	2.41 ± 1.15
Pancreas	0.56 ± 0.12	0.53 ± 0.32	0.71 ± 0.16	0.54 ± 0.22	0.74 ± 0.23
Stomach	0.87 ± 0.43	1.03 ± 0.38	1.10 ± 0.26	0.60 ± 0.26	0.95 ± 0.20
Intestine	2.80 ± 1.14	2.15 ± 0.71	2.12 ± 1.24	1.00 ± 0.40	1.19 ± 0.35
Brain	0.23 ± 0.16	0.27 ± 0.14	0.19 ± 0.06	0.27 ± 0.08	0.50 ± 0.09

Values are reported as %ID/g (mean ± SD).