Table S4.
Ex vivo biodistribution-derived tumor-to-normal tissue ratios for the three tracers 36 h after i.v. administration
| Tumor-to-normal tissue ratio | 64Cu-NOTA-Bs-F(ab)2; *D > 5 mm; n = 4 | 64Cu-NOTA-Bs-F(ab)2; *D < 5 mm; n = 4 | 64Cu-NOTA-CET-Fab, n = 3 | 64Cu-NOTA-TRC105-Fab, n = 4 |
| Tumor/muscle | 120.15 ± 44.39 | 76.40 ± 52.3 | 47.58 ± 20.11 | 22.47 ± 16.07 |
| Tumor/blood | 19.11 ± 17.32 | 3.63 ± 1.25 | 3.65 ± 2.61 | 3.10 ± 2.64 |
| Tumor/skin | 19.42 ± 5.52 | 16.83 ± 5.94 | 9.62 ± 9.93 | 5.20 ± 2.69 |
| Tumor/bone | 30.65 ± 17.70 | 38.08 ± 15.46 | 13.92 ± 16.01 | 14.60 ± 9.23 |
| Tumor/heart | 20.21 ± 6.10 | 13.38 ± 4.83 | 9.92 ± 6.74 | 5.99 ± 4.08 |
| Tumor/lung | 27.47 ± 27.64 | 11.85 ± 3.18 | 8.22 ± 5.45 | 9.60 ± 9.29 |
| Tumor/liver | 5.09 ± 1.41 | 3.45 ± 1.25 | 3.15 ± 0.82 | 2.48 ± 1.52 |
| Tumor/kidney | 6.07 ± 1.57 | 4.52 ± 2.69 | 2.68 ± 1.04 | 0.70 ± 0.45 |
| Tumor/spleen | 8.58 ± 6.60 | 11.81 ± 8.00 | 4.92 ± 4.26 | 3.58 ± 2.55 |
| Tumor/pancreas | 76.43 ± 1.02 | 56.82 ± 30.69 | 43.97 ± 41.29 | 16.62 ± 13.29 |
| Tumor/stomach | 54.25 ± 13.80 | 47.80 ± 28.84 | 17.61 ± 11.83 | 9.76 ± 5.09 |
| Tumor/intestine | 20.99 ± 18.62 | 22.29 ± 9.38 | 7.33 ± 4.57 | 5.18 ± 1.53 |
| Tumor/brain | 282.17 ± 169.56 | 120.21 ± 126.59 | 44.83 ± 30.68 | 64.09 ± 45.69 |
*
D, tumor diameter.