Table S1.
List of shRNAs used for screening E3 ligase function
| Target genes | shRNA sequences | Sequence ID |
| TRAF6 | CCGGCCCAGGCTGTTCATAATGTTACTCGAGTAACATTATGAACAGCCTGGGTTTTTG | NM_009424.2–1227s1c1 |
| TRAF6 | CCGGGCCTGCATCATCAAATCCATACTCGAGTATGGATTTGATGATGCAGGCTTTTTG | NM_009424.2–680s1c1 |
| TRIM50 | CCGGCGGATTATTAATGAGTCCGATCTCGAGATCGGACTCATTAATAATCCGTTTTTG | NM_178240.1–487s1c1 |
| TRIM25 | CCGGCCTGGAGTACAAACTGAGGAACTCGAGTTCCTCAGTTTGTACTCCAGGTTTTTG | NM_009546.1–597s1c1 |
| TRIM28 | CCGGCCACCAGTCTTCAAGGTCTTTCTCGAGAAAGACCTTGAAGACTGGTGGTTTTTG | NM_011588.1–2065s1c1 |
| TRIM13 | CCGGGCAGGTCAATTACTCCCTAAACTCGAGTTTAGGGAGTAATTGACCTGCTTTTTG | NM_023233.1–331s1c1 |
| CULLIN3 | CCGGGTGCGAGAAGATGTACTAAATCTCGAGATTTAGTACATCTTCTCGCACTTTTTG | NM_016716.4–384s21c1 |
| TRIM30 | CCGGGAGAACCAAATACAGATCAATCTCGAGATTGATCTGTATTTGGTTCTCTTTTTG | NM_009099.2–742s21c1 |
| TRIM21 | CCGGTTGTCTCCTTCTACAACATAACTCGAGTTATGTTGTAGAAGGAGACAATTTTTG | NM_009277.3–1421s21c1 |
| TRIM21 | CCGGTGACAATGAGGAGAGGTTTAGCTCGAGCTAAACCTCTCCTCATTGTCATTTTTG | NM_009277.3–1131s21c1 |
| TRIM21 | CCGGGAACCTGGACACGTTAGATATCTCGAGATATCTAACGTGTCCAGGTTCTTTTTG | NM_009277.3–945s21c1 |
| STUB1 | CCGGGAGAGTTATGATGAGGCCATTCTCGAGAATGGCCTCATCATAACTCTCTTTTT | NM_019719.2–833s1c1 |