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(A) Remodeling of live mammalian cell surfaces via site-specific ligation of tetrazine-modified synthetic mucin 5 to a norbornene-bearing engineered membrane protein. (B) Synthetic procedure for modification of dual end-functionalized poly(α-GalNAc-Ser)s with a CF647 optical probe for visualization and a tetrazine moiety for covalent attachment to norbornene.
